Unveiling the intricacy of gapmer oligonucleotides through advanced tandem mass spectrometry approaches and scan accumulation for 2DMS

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Abstract
Multimodal tandem mass spectrometry sequencing of oligonucleotides using CID, EDD, IRMPD, and UVPD as fragmentation methods, and using 2-dimensional mass spectrometry with signal averaging to differentiate fragments from closely spaced precursors.
Funding Information
  • University of Warwick
  • Engineering and Physical Sciences Research Council (J000302/1, V007688/1, V007718/1, N033191/1)
  • Biotechnology and Biological Sciences Research Council (R022399/1, V011456/1)
  • Horizon 2020 Framework Programme (731077)

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