Stéfane Lele Rossoni

Objetivo: mapear as evidências disponíveis na literatura científica sobre instrumentos utilizados por enfermeiros na consulta de pré-natal na Atenção Primária à Saúde, fundamentados no Processo de Enfermagem. Método: revisão de escopo conduzida conforme metodologia do JBI e reportada segundo o PRISMA-ScR. Desenvolveu-se entre setembro de 2024 e julho de 2025, com protocolo registrado no Open Science Framework (OSF). A busca ocorreu nas fontes de informação: PubMed, CINAHL, Scopus, Web of Science, Embase, LILACS, literatura cinzenta e rastreamento manual, seguindo as etapas de identificação, seleção, elegibilidade e inclusão. Foram incluídas publicações originais sobre instrumentos para consulta de enfermagem no pré-natal de risco habitual. Resultados: identificaram-se cinco estudos nacionais que propuseram guias, fichas clínicas, roteiros e históricos de enfermagem, ancorados na Teoria das Necessidades Humanas Básicas e CIPESC®. Conclusão: os instrumentos contribuem para a organização da assistência, porém não contemplam integralmente as etapas do Processo de Enfermagem.

(1) Background: Chemotherapy-induced hematological toxicity remains a major limitation to treatment continuity. Docetaxel is widely used in solid tumors due to its clinical efficacy, despite cumulative bone marrow suppression and splenic alterations. Curcuma longa is a phytochemical with antioxidant and anti-inflammatory properties that may confer cytoprotective effects on hematopoietic tissues. (2) Methods: One hundred and five male Wistar rats were randomly allocated into five treatment groups and evaluated at 7, 14, and 21 days. Animals received placebo, docetaxel alone, or docetaxel combined with Curcuma longa at doses of 25, 50, or 500 mg/kg/day. Post-treatment hematological parameters and relative spleen weight were analyzed using one-way ANOVA and Tukey’s post hoc test. (3) Results: Docetaxel induced progressive reductions in red blood cell count, hemoglobin, hematocrit, leukocytes, and platelets, with greater severity at day 21. Curcuma longa co-treatment partially mitigated these alterations in a dose- and time-dependent manner. Intermediate doses (25–50 mg/kg) showed the most consistent hematoprotective effects. High-dose treatment (500 mg/kg) was associated with no statistically significant change in relative spleen weight. (4) Conclusions: Curcuma longa partially mitigated docetaxel-induced hematological toxicity and modulated splenic responses in this experimental model. These findings support further translational studies on chemotherapy-induced hematological toxicity to clarify the role of Curcuma longa as a low-toxicity strategy.

One of the challenges post-COVID-19 is reducing the negative impacts on quality of life, performance, and independence in activities of daily living. Assessing functional dependence in adults one year after acute infection can help to understand the long-term consequences, evaluate the impact on quality of life, plan rehabilitation and healthcare, identify the most vulnerable groups, measure the socioeconomic impact, and support public policies and clinical decisions. Objectives: The objectives of this study are as follows: (a) to assess the prevalence of functional dependence in Brazilian adults with COVID-19; (b) to analyze the association between the study variables; and (c) to determine the factors associated with functional dependence. Methods: This was an observational, cross-sectional study with 987 adults (18 to 59 years old) living in the State of Paraná (Brazil) hospitalized for COVID-19 between March and December 2020. Data were collected by telephone 12 months after the acute infection using an instrument to retrieve sociodemographic and health information, and a functional dependence scale to assess dependence before COVID-19 retrospectively (using participant recall information) and at the time of the interview. Data were analyzed using penalized logistic regression after imputing missing data. Data were analyzed using penalized logistic regression after imputing missing data. Results: Functional dependence after COVID-19 was 5.0% and was associated with low levels of education, not having a partner, living with someone, not owning a home, experiencing job changes, requiring care, obesity, smoking, multimorbidity, ICU admission in the acute phase, use of invasive ventilation, or having Long COVID. Individuals who required care or used invasive ventilation support were, respectively, 9.3 and 6.5 times more likely to develop dependence after COVID-19. Despite adjustment for multiple factors, the magnitude of the observed effects warrants cautious interpretation, as unmeasured or residual confounding effects may still be present. Sample recall bias due to collection after 12 months and the presence of the alpha variant without COVID-19 vaccination coverage may limit data generalization. Conclusions: The results highlight the need to emphasize the public health implications of identifying functional dependence. In this vein, it is necessary to implement preventive measures, identify and monitor more vulnerable groups, plan rehabilitation programs, and develop public health policies.

Resumo Objetivo: analisar os fatores associados ao óbito de pessoas idosas hospitalizadas por COVID-19 no Brasil. Método: estudo transversal conduzido com dados secundários de domínio público de pessoas idosas hospitalizadas que evoluíram a óbito por COVID-19. As razões de chances foram obtidas por meio do ajuste de modelo de regressão logística. Resultados: a análise foi composta por 468.239 óbitos de pessoas idosas hospitalizadas no Brasil. Alguns fatores foram associados ao óbito, tais como: idade entre 75 e 84 anos (OR=1,77; IC95%=1,74-1,79) e 85 anos ou mais (OR=3,01; IC95%=2,96-3,06); raça/cor branca (OR=1,11; IC95%=1,05-1,17), indígena (OR=1,54; IC95%=1,34-1,76), parda (OR=1,28; IC95%=1,22-1,35) e preta (OR=1,48; IC95%=1,39-1,57); sexo masculino (OR=1,27; IC95%=1,25-1,28); vacina contra a COVID-19 (OR=0,68; IC95%=0,67-0,69); uso de suporte ventilatório invasivo (OR=19,54; IC95%=19,14-19,95) e não invasivo (OR=1,78; IC95%=1,75-1,80). Conclusão: identificou-se associação entre idade, sexo, raça/cor, vacina contra a COVID-19 e uso de suporte ventilatório com o óbito por COVID-19.

Objective: to analyze the factors associated with death among hospitalized older adults with COVID-19 in Brazil. Method: a cross-sectional study conducted using publicly available secondary data from hospitalized older adults who died from COVID-19. Odds ratios were obtained through the adjustment of a logistic regression model. Results: the analysis comprised 468,239 deaths of hospitalized older adults in Brazil. Some factors were associated with death, such as: age between 75 and 84 years (OR=1.77; 95% CI=1.74-1.79) and 85 years or older (OR=3.01; 95% CI=2.96-3.06); race/ethnicity White (OR=1.11; 95% CI=1.05-1.17), Indigenous (OR=1.54; 95% CI=1.34-1.76), Brown (OR=1.28; 95% CI=1.22-1.35), and Black (OR=1.48; 95% CI=1.39-1.57); male sex (OR=1.27; 95% CI=1.25-1.28); COVID-19 vaccination (OR=0.68; 95% CI=0.67-0.69); use of invasive ventilatory support (OR=19.54; 95% CI=19.14-19.95) and non-invasive ventilatory support (OR=1.78; 95% CI=1.75-1.80). Conclusion: an association was identified between age, sex, race/ethnicity, COVID-19 vaccination, and the use of ventilatory support with COVID-19-related death.

Resumen Objetivo: analizar los factores asociados a la muerte de personas mayores hospitalizadas por COVID-19 en Brasil. Método: estudio transversal realizado con datos secundarios de dominio público de personas mayores hospitalizadas que evolucionaron a muerte por COVID-19. Las razones de probabilidades se obtuvieron mediante el ajuste de modelo de regresión logística. Resultados: el análisis estuvo compuesto por 468.239 muertes de personas mayores hospitalizadas en Brasil. Algunos factores se asociaron con la muerte, tales como: edad entre 75 y 84 años (OR=1,77; IC95%=1,74-1,79) y 85 años o más (OR=3,01; IC95%=2,96-3,06); raza/color blanca (OR=1,11; IC95%=1,05-1,17), indígena (OR=1,54; IC95%=1,34-1,76), parda (OR=1,28; IC95%=1,22-1,35) y negra (OR=1,48; IC95%=1,39-1,57); sexo masculino (OR=1,27; IC95%=1,25-1,28); vacuna contra la COVID-19 (OR=0,68; IC95%=0,67-0,69); uso de soporte ventilatorio invasivo (OR=19,54; IC95%=19,14-19,95) y no invasivo (OR=1,78; IC95%=1,75-1,80). Conclusión: se identificó asociación entre edad, sexo, raza/color, vacunación contra la COVID-19 y uso de soporte ventilatorio con la muerte por COVID-19.

Resumo Objetivo: Correlacionar o uso de práticas integrativas e complementares (PIC) e os atendimentos de hipertensão, bem como sua correlação com indicadores socioeconômicos no Brasil em 2023. Métodos: Estudo ecológico com dados do Sistema de Informação em Saúde para a Atenção Básica. Foram analisados os atendimentos de PIC e de hipertensão, além dos indicadores socioeconômicos indice de desenvolvimento humano municipal (IDHM) e produto interno bruto (PIB) per capita. Foram descritas as taxas de PIC e de hipertensão, com aplicação do coeficiente de correlação de Pearson para avaliar as correlações entre as variáveis, além de análise de variância e análise espacial por meio do índice de Moran global e dos indicadores locais de associação espacial. Resultados: Foram registrados 78.496 atendimentos de PIC, com maior taxa no Rio Grande do Sul (271,75/100 mil habitantes). Para hipertensão, o Ceará registrou a maior taxa (64.409/100 mil habitantes). Observou-se correlação positiva entre PIC e hipertensão (ρ=0,201; p-valor 0,010), bem como com o IDHM (ρ=0,426; p-valor 0,026) e o PIB per capita (ρ=0,443; p-valor 0,020). Conclusão: Houve correlação positiva entre o uso de PIC, os atendimentos por hipertensão e os indicadores socioeconômicos, o que evidenciou desigualdades regionais na oferta dessas práticas no Brasil.

Objective: To correlate use of integrative and complementary practices (ICP) and hypertension consultations, as well as their correlation with socioeconomic indicators in Brazil in 2023. Methods: This was an ecological study with data from the Primary Health Care Information System. ICP and hypertension care were analyzed, in addition to the following socioeconomic indicators: municipal human development index (MHDI) and gross domestic product per capita (GDP). ICP and hypertension rates were described, applying Pearson’s correlation coefficient to assess correlations between variables, in addition to analysis of variance and spatial analysis using global Moran’s I and local indicators of spatial association. Results: 78,496 ICP consultations were recorded, with the highest rate in Rio Grande do Sul state (271.75/100,000 inhabitants). Regarding hypertension consultations, Ceará state recorded the highest rate (64,409/100,000 inhabitants). Positive correlation was observed between ICP and hypertension (ρ=0.201; p-value 0.010), as well as with MHDI (ρ=0.426; p-value 0.026) and GDP per capita (ρ=0.443; p-value 0.020). Conclusion: There was positive correlation between use of PIC, hypertension consultations and socioeconomic indicators, highlighting regional inequalities in the provision of these practices in Brazil.

Docetaxel is a widely used chemotherapeutic agent effective against sol-id tumors, but its clinical use is limited by systemic toxicities, especially hepatotoxicity and nephrotoxicity. Curcuma longa, a phytochemical with antioxidant and anti-inflammatory properties, may offer organo-protective effects. Objective: To evaluate the protective effects of orally administered Curcuma longa against docetaxel-induced systemic toxicity in Wistar rats. Methods: Male Wistar rats were assigned to 5 subgroups (n=7/group) and treated for 7, 14, or 21 days with placebo, docetaxel (2.5 mg/kg, i.p.), or docetaxel combined with Curcuma longa (25, 50, or 500 mg/kg/day, oral). Serum biomarkers of hepatic function (Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT_, bilirubins) and renal function (urea, creatinine, electrolytes) were evaluated using summary measures, ANOVA, and Tukey’s post-hoc test, in addition to the relative weights of the liver, kidneys, heart, lungs, and small intes-tine. Results: Docetaxel induced significant elevations in hepatic and renal biomarkers and altered organ weights. Curcuma longa co-treatment attenuated these effects in a dose- and time-dependent man-ner. The 50 mg/kg dose consistently provided optimal protection. High-dose treatment was associated with marked splenic and intestinal hy-pertrophy. Conclusion: Curcuma longa demonstrates cytoprotective po-tential against docetaxel-induced toxicity, likely via Nrf2, NF-κB, and PI3K/Akt modulation. These findings support further translational re-search on Curcuma longa as an adjuvant in oncologic therapy.

To analyze the incidence of Severe Acute Respiratory Syndrome (SARS), lethality and mortality of Brazilian pregnant and postpartum women infected with SARS-CoV-2, before and after vaccination against Covid-19. This is an ecological study of time series, carried out with secondary data from the Brazilian Ministry of Health, from March 2020 to April 2024. Slopes and trend changes in the time series were identified by Mann-Kendall and generalized fluctuation tests, respectively. The series was modeled using Generalized Additive Models with interaction between time and start of vaccination. A Pearson correlation was used between the number of accumulated doses and the incidence, lethality and mortality rates, in addition to comparing the average rates before and after the vaccination peak of the first dose using ANOVA. Significant temporal variations were observed in the incidence rates of SARS, lethality and mortality in pregnant and postpartum women with SARS-CoV-2, before and after vaccination against Covid-19 in Brazil, with a significant decreasing trend after the start of vaccination. It was observed that time alone did not show a significant effect on the reduction of lethality and mortality rates, which occurred only when there was an interaction effect between time and the start of vaccination. The accumulated doses of the vaccine correlated with the decrease in the analyzed rates, which explained 39.18% of variation in the incidence rate, 43.34% in the lethality rate, and 34.81% in the mortality rate. The monthly averages of the incidence, lethality, and mortality rates before and after vaccination reduced significantly. The findings of this study indicate that vaccination against Covid-19 in Brazilian pregnant and postpartum women had a positive effect on reducing the incidence of SARS by SARS-CoV-2, lethality and mortality rates in the obstetric population.